Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective
… Atrial fibrous-tissue content is increased in patients with pAF and atrial scarring correlates
with … At the same time, spontaneous atrial ectopic activity seems to be an important trigger for …
with … At the same time, spontaneous atrial ectopic activity seems to be an important trigger for …
[HTML][HTML] Molecular insights in atrial fibrillation pathogenesis and therapeutics: a narrative review
KA Papathanasiou, SG Giotaki, DA Vrachatis, G Siasos… - Diagnostics, 2021 - mdpi.com
… is critical in triggering DADs and thus increased atrial ectopic activity. In human AF models,
… fibroblasts and epicardial adipose tissue (EAT) are positively correlated with atrial fibrosis …
… fibroblasts and epicardial adipose tissue (EAT) are positively correlated with atrial fibrosis …
Comprehensive evaluation of electrophysiological and 3D structural features of human atrial myocardium with insights on atrial fibrillation maintenance mechanisms
… mechanisms that mediate formation and propagation of ectopic activation and reentry … was
found to be inversely correlated with atrial Cx40 expression [103]. Lastly, patients with AF and …
found to be inversely correlated with atrial Cx40 expression [103]. Lastly, patients with AF and …
[HTML][HTML] The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives
N Li, L Wang, L Li, MZ Yang, QX Wang, XW Bai… - Military Medical …, 2023 - Springer
… The incidence and prevalence of atrial fibrillation (AF) are continuously escalating as the …
In this review, we summarized the evidence for a bidirectional correlation between AF and the …
In this review, we summarized the evidence for a bidirectional correlation between AF and the …
[HTML][HTML] Altered calcium handling produces reentry-promoting action potential alternans in atrial fibrillation–remodeled hearts
T Liu, F Xiong, XY Qi, J Xiao, L Villeneuve, I Abu-Taha… - JCI insight, 2020 - ncbi.nlm.nih.gov
… Ca 2+ releases, causing spontaneous atrial ectopic activity, but also promote alternans …
SERCA2a downregulation is a principal correlate of repolarization alternans in heart failure (…
SERCA2a downregulation is a principal correlate of repolarization alternans in heart failure (…
Coronary heart disease and atrial fibrillation: a vicious cycle
F Liang, Y Wang - American Journal of Physiology-Heart …, 2021 - journals.physiology.org
… (CHD) complicated by atrial fibrillation (AF) is rising rapidly. A strong correlation between the
two … In summary, research on focal ectopic activity after ACS is still inconclusive, and it may …
two … In summary, research on focal ectopic activity after ACS is still inconclusive, and it may …
[HTML][HTML] The therapeutic potential of microRNAs in atrial fibrillation
X Xu, Z Zhao, G Li - Mediators of inflammation, 2020 - hindawi.com
… AF is the most common cardiac arrhythmia, correlated with increased morbidity and …
overactive ectopic pacemakers cause ectopic activity. In normal atrial tissue, enhanced ectopy or …
overactive ectopic pacemakers cause ectopic activity. In normal atrial tissue, enhanced ectopy or …
[HTML][HTML] Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology
… Increased atrial ectopy 44,45,46 in experimental pericarditis is associated with DADs and
cellular triggered activity 47 . Atrial structural remodelling in these animal models is …
cellular triggered activity 47 . Atrial structural remodelling in these animal models is …
[HTML][HTML] microRNAs as Biomarkers of Endothelial Dysfunction and Therapeutic Target in the Pathogenesis of Atrial Fibrillation
V Desantis, MA Potenza, L Sgarra, C Nacci… - … Journal of Molecular …, 2023 - mdpi.com
… may induce atrial ectopic activity via multiple … correlation is found between NFkB activity,
serum TNF-α, and IL-6 levels and collagen volume fraction in atrial tissue from AF patients with …
serum TNF-α, and IL-6 levels and collagen volume fraction in atrial tissue from AF patients with …
Left atrial fibrosis in atrial fibrillation: Mechanisms, clinical evaluation and management
J Ma, Q Chen, S Ma - Journal of cellular and molecular …, 2021 - Wiley Online Library
… 426 patients followed up for 1 year demonstrated that recurrent arrhythmias are strongly
correlated with … These processes could participate in induced activity or ectopic focal discharges …
correlated with … These processes could participate in induced activity or ectopic focal discharges …